Сomputational Postdoctoral Fellow

Company Description

UHN is Canada’s #1 hospital and the world’s #1 publicly funded hospital. With 10 sites and more than 44,000 TeamUHN members, UHN consists of Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute, The Michener Institute of Education and West Park Healthcare Centre. As Canada's top research hospital, the scope of biomedical research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. UHN has the largest hospital-based research program in Canada, with major research in neurosciences, cardiology, transplantation, oncology, surgical innovation, infectious diseases, genomic medicine and rehabilitation medicine. UHN is a research hospital affiliated with the University of Toronto.

UHN’s vision is to build A Healthier World and it’s only because of the talented and dedicated people who work here that we are continually bringing that vision closer to reality.

www.uhn.ca

Job Description

As part of The Princess Margaret Cancer Centre, one of the top 5 cancer research centres in North America, the Principal Investigator is currently seeking applications for a computational postdoctoral fellow with expertise in cancer epigenomics, chromatin biology, and data-driven research.

The Lupien Laboratory is dedicated to uncovering the epigenetic mechanisms driving cancer development, progression, and therapeutic resistance. Using cutting-edge computational and experimental approaches, our team seeks to decode epigenomic heterogeneity and identify novel vulnerabilities that can be targeted for precision oncology.

Research Focus & Responsibilities

The successful candidate will:

• Lead independent computational research projects focused on the role of epigenetic heterogeneity in cancer initiation, progression, and treatment response.
• Develop and apply computational pipelines for analyzing single-cell and bulk epigenomic datasets, including scMultiome, Spatial ATACseq, ChIP-seq, Hi-C, and DNA methylation data.
• Integrate multi-omics datasets to explore chromatin dynamics and transcriptional regulation in hormone-dependent cancers and other aggressive malignancies.
• Work closely with wet lab scientists to guide experimental design and validate computational predictions.
• Develop innovative machine learning and statistical models to characterize epigenomic heterogeneity and treatment resistance mechanisms.
• Present findings at international conferences and contribute to high-impact publications.

By joining the Lupien Lab, you will benefit from:

• A Multidisciplinary Team – Our group integrates computational and experimental scientists to develop cutting-edge chromatin and epigenetics research.
• Clinical & Industry Partnerships – We collaborate with clinician-scientists, biotech companies, and AI researchers to translate discoveries into precision oncology.
• State-of-the-Art Resources – The Princess Margaret Cancer Centre provides high-performance computing, single-cell sequencing, and advanced AI platforms.
• A Prime Research Hub – Located in Toronto, a world-leading city biomedical innovation, offering unmatched professional growth.

Qualifications

We are looking for a motivated and creative postdoctoral fellow with:

• A PhD in bioinformatics, computational biology, cancer genomics, or a related field.
• Experience in analyzing epigenomic data (ATAC-seq, ChIP-seq, Hi-C, DNA methylation, or single-cell sequencing).
• Strong programming skills in Python, R, or equivalent.
• Knowledge of statistical and machine learning methods for multi-omics data integration is an asset.
• A passion for collaborative and translational research in cancer epigenomics.

Additional Information

Why join UHN?

In addition to working alongside some of the most talented and inspiring healthcare professionals in the world, UHN offers a wide range of benefits, programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN.

• Competitive offer packages
• Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP https://hoopp.com/)
• Close access to Transit and UHN shuttle service
• A flexible work environment
• Opportunities for development and promotions within a large organization
• Additional perks (multiple corporate discounts including: travel, restaurants, parking, phone plans, auto insurance discounts, on-site gyms, etc.)

Current UHN employees must have successfully completed their probationary period, have a good employee record along with satisfactory attendance in accordance with UHN's attendance management program, to be eligible for consideration.

All applications must be submitted before the posting close date.

UHN uses email to communicate with selected candidates.  Please ensure you check your email regularly.

Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading, inaccurate or incorrect, UHN reserves the right to discontinue with the consideration of their application.

UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.

We thank all applicants for their interest, however, only those selected for further consideration will be contacted.