Scientist II, Genomics

Why Sarepta? Why Now?
The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold leadership positions in Duchenne muscular dystrophy (DMD) and limb-girdle muscular dystrophies (LGMDs), and we currently have more than 40 programs in various stages of development in gene therapy, RNA and gene editing. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.
 

We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.
 

What Sarepta Offers

At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:

• Physical and Emotional Wellness

• ​Financial Wellness

• Support for Caregivers
   

For a full list of our comprehensive benefits, see our website: https://www.sarepta.com/join-us
 

The Importance of the Role

The Clinical Genomic scientist will leverage their expertise in clinical genomics and genetic epidemiology to navigate the complexities of rare disease. This role involves conducting studies to assess genotype-phenotype associations, estimate variant frequencies, and make data-driven decisions to support numerous precision therapies under development for rare disease. The insights gained from these studies will enhance our understanding of clinical responses to therapies, ultimately benefiting patient treatment. By applying advanced analytical techniques, you will also contribute to the genetic assessment of current and future precison medicine indications.

The Opportunity to Make a Difference

• Design and execute genomic studies to assess genotype-phenotype associations, estimate variant frequencies, and model disease prevalence using real-world, epidemiological, and clinical data. 

• Collaborate across scientific and clinical teams, including biometrics, biomarkers, clinical development, and commercial teams, to develop and implement genotype-phenotype analyses that support therapeutic programs. 

• Interpret and describe diagnostic reports from genetic testing performed across the globe. 

• Leverage publicly available genetic datasets, including gnomAD, UK Biobank, and other biobanks, to support data-driven insights for clinical and research initiatives. 

• Contribute to clinical trial design by supporting the development of genetically informed inclusion and exclusion criteria. 

• Support regulatory efforts by contributing to the preparation and review of regulatory submissions, reports, and scientific documentation. 

• Conduct comprehensive literature reviews to investigate disease biology, progression, and treatment safety, synthesizing insights to inform research and therapeutic strategies. 

• Oversee project timelines and deliverables, coordinating with technical and scientific vendors, managing sample workflows in collaboration with research operations, and ensuring alignment with internal stakeholders. 

• Generate high-quality research reports and contribute to scientific publications, effectively communicating findings to internal teams and the broader scientific community. 

• Represent Genomics and Data Science on cross-functional program teams, providing expertise in genetic data analysis and interpretation to guide decision-making. 

• Perform other related duties as assigned, contributing to the continuous evolution of genomic research and its application to therapeutic development.  

More about You

• Ph.D. in Genetics, Computational Biology, Statistical Genomics, or a related field with strong expertise in human genetics and data analysis. 

• Equivalent industry experience in genetic data science, translational research, or clinical genomics will be considered. 

• Expertise in rare disease genomics, including variant analysis, genotype-phenotype associations, and disease prevalence estimation. 

• Strong programming skills in R or Python for analyzing large genomic datasets, with best practices for reproducible and efficient coding. 

• Experience managing and analyzing large-scale genomic and clinical datasets, including exome and whole-genome sequencing data. 

• Proven ability to manage multiple complex projects simultaneously, ensuring timely execution and delivery of research goals. 

• Excellent written and verbal communication skills, with the ability to present findings clearly to scientific and non-scientific audiences. 

• Strong organizational and documentation skills, ensuring research processes and methodologies are well-documented and reproducible. 

• Pharmaceutical industry experience, particularly in translational genomics, clinical genetics, or biomarker development is highly preferred. 

• Experience with cloud computing and shared coding environments, such as AWS, Google Cloud, or other scalable genomic data platforms is preferred. 

• Familiarity with DNAnexus and large biobank datasets, including UK Biobank, for large-scale genomic research is preferred. 

• Knowledge of regulatory requirements for genetic data interpretation and experience contributing to regulatory documentation is preferred. 

• Hands-on experience with computational pipelines for variant calling, annotation, and interpretation in rare disease contexts is preferred. 

What Now?

We’re always looking for solution-oriented, critical thinkers.

So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.
 

#LI-Hybrid

#LI-PM1

This position is hybrid, you will be expected to work on site at one of Sarepta’s facilities in the United States and/or attend Company-sponsored in-person events from time to time.

The targeted salary range for this position is $108,000 - $135,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.

Candidates must be authorized to work in the U.S.

Sarepta Therapeutics offers a competitive compensation and benefit package.

Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.