Director, Bioinformatics and Computational Biology

Who We Are:

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.

What We Do:

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X and Facebook. (*in collaboration with AbbVie)

About the Role:

The Director of Bioinformatics and Computational Biology will advance cutting-edge discovery and development by combining deep computational expertise with strategic leadership. Located within IT Data Solutions to ensure enterprise-wide support, this role collaborates closely with R&D to fuel breakthroughs using multi-omics, genetic variation, and disease pathway analyses. By shaping computational strategies and developing innovative tools, the Director will play a pivotal role in identifying and validating novel therapeutic targets, ultimately accelerating the organization’s drug discovery and development pipeline.

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Your Contributions (include, but are not limited to):

• Oversee and mentor a growing team of bioinformaticians and computational biologists, ensuring the team’s expansion aligns with the evolving needs of the research organization

• Contribute to the computational biology strategy for target identification across all programs of interest to Neurocrine Biosciences.

• Design and implement computational approaches to analyze complex multi-omics datasets—including genomics, transcriptomics, proteomics, and single-cell RNA sequencing—across preclinical models and human data

• Direct the computational pipeline and workflow development to integrate internal and external datasets, including AI/ML approaches to accelerate target identification and validation

• Establish and maintain collaborations with internal teams and external partners, including academic institutions and contract research organizations

• Champion project-focused metrics (e.g., novel targets, pipeline throughput, predictive accuracy), ensuring alignment with strategic goals and maximizing drug discovery impact

Requirements:

• PhD in Computational Biology, Bioinformatics, or related field and 7+ years of experience in research, drug discovery and development OR

• Master's Degree in Computational Biology, Bioinformatics, or related field and 10+ years as noted above

• Deep expertise in multi-omics analysis (i.e. genomics, transcriptomics, single-cell RNA-seq, GWAS) with a proven track record in target identification and drug discovery

• Expert in bioinformatics tools (e.g., R, Python) and in integrating diverse datasets for biological insights

• Strong understanding of disease biology, with a demonstrated drive to learn across therapeutic areas

• Proven leadership and collaboration skills, including building high-performing teams and effective cross-functional communication

• Experience applying AI/ML and advanced statistical methods to drug discovery, including predictive modeling, data mining, and analytics for novel target identification

• Familiarity with modern computing environments (e.g., cloud, HPC) and scalable workflows for large-scale data processing

• Demonstrable track record of successful contributions to drug discovery programs

• Ability to distill complex problems and strong problem-solving skills

• Builds strong collaborative relationships with functional stakeholders, i.e. Research, Clinical Development  

• High level understanding of the Regulatory environment, biopharmaceutics landscape, competitive environment, and knowledge of drug development stages

• Effective communications and presentation skills

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Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description.

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The annual base salary we reasonably expect to pay is $182,400.00-$264,050.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 35% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.