Scientist - Analytical Functional Genomics

Career Category

Scientific

Job Description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Scientist - Analytical Functional Genomics

What you will do

Let’s do this. Let’s change the world. The Amgen Functional Genomics organization is seeking a highly motivated scientist to join the research team at our facility in South San Francisco. This Scientist will report to a Senior Manager in the Discovery Genomics team of Functional Genomics.

What you will do:

• Apply computational, statistical, and machine learning techniques for the analysis of internal and external omics datasets.
• Advance target discovery and mechanism of action studies by analyzing forward genetics screens supporting multiple therapeutic areas.
• Collaborate with internal computational groups to develop analytical frameworks for advanced perturbational techniques, including perturb-seq and opto-seq
• Provide data analytical support for functional genomics efforts in target discovery
• Support Functional Genomics pipelines by providing routine data QC or analyses, including bulk RNA-seq alignment, transcriptomic assessment of edited cell lines, and single cell multi-omics.
• Support NGS data management through experimental registration and sample tracking using established platforms, ensuring data integrity, standardization, and accessibility. Develop new data management frameworks as NGS methods and data structures evolve.
• Communicate research findings to subject matter experts across therapeutic areas through internal and external meetings and publish scientific findings in peer-reviewed forums.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is an experienced Scientist with these qualifications.

Basic Qualifications:

Doctorate degree or

Master’s degree and 2 years of experience or

Bachelor’s degree and 4 years of experience

Preferred Qualifications:

• Doctorate degree in bioinformatics, genetics, genomics, computational biology or related disciplines.
• Demonstrated expertise in analyzing NGS data, including CRISPR, single-cell RNA-seq, epigenomics, spatial transcriptomics, bulk RNA-seq, and ability to connect modalities into large multi-omics approaches. Experience with single-cell CRISPR and optical screening analysis is preferred.
• Proficiency in leveraging existing bioinformatics tools and developing custom code to support NGS and functional genomics technology development.
• Strong programming skills in R and/or Python, experience with Unix/Linux environments, and experience working in a cloud computing environment.
• Experience with best practices for data integrity and reproducibility.
• Demonstrated expertise in critical thinking, complex problem-solving, and innovative data analysis, evidenced by significant contributions to scientific programs and publications in top-tier journals
• Expertise in experimental design and data analysis for perturbational studies and target discovery.
• Strong written, verbal, and interpersonal communication skills, with the ability to collaborate effectively across cross-functional teams.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models, including remote and hybrid work arrangements, where possible

Apply now and make a lasting impact with the Amgen team.

careers.amgen.com

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.

Salary Range

129,926.00 USD - 154,420.00 USD