Principal Scientist, Computational Biology - Genotoxicity

Your experience includes… 

• Ph.D. (or comparable experience) in Computational Biology, Bioinformatics, or related quantitative discipline.  
• 8+ years of experience in discovery research in an industrial or academic setting focused on gene therapy. 
• Proficient with experimental design, data processing, statistical analysis, and bioinformatics analysis/reporting of next-generation sequencing data. A strong experimental knowledge is welcome.
• Experienced in developing methodologies and analyzing data for genotoxicity assessments in gene editing applications.
• Experience developing and characterizing gene therapy platforms, preferably in the gene editing space.
• Expertise in the central concepts of data structures and cloud computing.
• Fluency in one or more programming languages with bioinformatics applications (R, Python). 
• Track record of success working in a fast-paced, cross-functional, and rapidly growing organization.
• Improved written and verbal communication skills, ability to work with colleagues from diverse scientific backgrounds and cultures.

You are interested in… 

• Significant experience with recent advances in gene therapy and development of gene editing platforms as therapeutics.
• Familiarity with computational methods for understanding molecular results of gene editing outcomes including on-target, off-target, and structural variants, from in silico to in cellula and in vitro methods.
• Familiarity with short and long read next-generation sequencing platforms (Illumina, PacBio, Nanopore).
• Proficiency in handling large scale sequencing data in a cloud environment (AWS preferred).
• Proficiency in statistics.
• It’s a bonus if you have experimental training.

About you: 

We are seeking a highly motivated scientist with a strong computational background and significant experience in biological research. As part of the Computational Biology team, you will collaborate closely with Platform teams to advance our technologies and deepen our understanding of reagent biology. Your role will involve (1) working with biologists to design experiments, (2) developing methods and tools for processing and interpreting molecular data, and (3) presenting findings to an interdisciplinary audience. Your curiosity and passion will fuel your discoveries, while strong connections with biologists and data/software engineers will amplify the impact of your work.
Tessera employees are creative and collaborative problem solvers. They have a strong sense of integrity and unwavering commitment to scientific excellence. 

Meet your Manager:
All inquiries regarding the posted position should be directed to the Talent Partner (see below). Interested individuals must apply directly to be considered for the opening. 

Andrea Calabria - Director, Computational Sciences 

Andrea holds a B.Sc. and M.Sc. in Engineering from the Polytechnic of Milan (Italy) and earned a Ph.D. in Computer Science from the University of Milan Bicocca (Italy), specializing in computational biology. He has over 11 years of postdoctoral experience in gene therapy at the San Raffaele Telethon Institute for Gene Therapy in Milan, where he became a recognized researcher (H-index: 24, ORCID: https://orcid.org/0000-0003-3515-3384). His work focused on assessing the safety and insertional mutagenesis of gene therapy treatments using viral vectors and investigating human hematopoietic stem cell differentiation in vivo through clonal dynamics.
Andrea joined Tesera in 2023 as the lead of the computational biology team, where he is responsible for:
1.    Supporting drug candidate programs by developing genotoxicity packages,
2.    Leading research projects to identify novel reagents and uncover their biological mechanisms, and
3.    Overseeing technical initiatives, including database development for knowledge mining and molecular assay design.

Meet our Leadership Team and Board of Directors 
 
Meet your Talent Partner:

Narissa Furtado-Cordeiro - Manager, Talent Acquisition 

Narissa joined the Biotechnology industry shortly after graduating with her BS in Marketing from Franklin Pierce University. She is currently pursuing a MS in Legal Studies from Northeastern University School of Law while working full time as a Manager in Talent Acquisition at Tessera. She is passionate about helping individuals find a fulfilling opportunity while considering their interests, aspirations and technical skills. Narissa lives in Northern Vermont and enjoys spending time outdoors with her husband, three-year-old daughter and German Shepherd.

Tessera offers a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits currently include group medical, vision and dental coverage, group life and disability insurance, 401(k) with company contribution, tuition reimbursement, and much more.

Company Summary:

Tessera Therapeutics is pioneering Gene Writing™— a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy. Tessera Therapeutics was founded by Flagship Pioneering, a life sciences innovation enterprise that conceives, resources, and develops first-in-category companies to transform human health and sustainability.

More about Tessera Therapeutics:

Tessera is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, marital status, genetics, protected veteran status, citizenship status, sexual orientation, gender identity or expression, or any other characteristic identified by federal, state, or local laws where we operate. Tessera provides reasonable accommodations to qualified applicants and employees with disabilities. To begin an interactive dialogue with Tessera regarding a reasonable accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied, please contact the recruiter or Accommodations@tesseratx.com

Recruitment & Staffing Agencies:  Tessera Therapeutics does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Tessera Therapeutics or its employees is strictly prohibited unless contacted directly by Tessera Therapeutics’ internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Tessera Therapeutics, and Tessera Therapeutics will not owe any referral or other fees with respect thereto.