Scientist, Morphological Profiling / High-Content Imaging

Who We Are:

Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science, and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.

Position Description:

Calico is seeking a Scientist to join the Cellular Phenotyping (CP) group. Our lab applies high-content imaging and phenotypic screening to better understand age-related processes and identify opportunities for therapeutic interventions. Your responsibilities will include implementing strategically useful cell culture models and using high-throughput microscopy-based approaches for characterizing cellular phenotypes. This role will require integration of cutting-edge cell culture methods with rapidly evolving approaches to image analysis. The ideal candidate has a broad technical background that will enable effective collaboration between life scientists, data scientists, machine learning engineers and automation engineers. To succeed in this role, you will need to be self-motivated, collaborative and enthusiastic about technology.

Position Requirements:

• Ph.D. degree in biology or bioengineering plus 0-5 years of relevant postdoctoral or industry experience
• Experience with high-content imaging or automated microscopy
• Experience with basic image analysis (segmentation, feature extraction, quantification)
• Track record of productivity and effective collaboration
• Ability to work flexibly in a fast-paced environment with shifting priorities
• Clear verbal and written communication skills
• Attention to detail, time management and organization skills are a must
• Must be willing to work onsite 5 days a week

Nice to Have:

• Advanced tissue culture models including any/all of the following: iPSC-derived disease models, spheroid/organoid models, co-culture systems
• Plate-based phenotypic screening
• CRISPR gene editing methods
• Unbiased profiling technologies such as RNAseq, proteomics or metabolomics
• Common lab automation, such as liquid handling
• Programming in Python and the fundamentals of machine learning concepts

The estimated base salary range for this role is $135,000 - $163,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.