Sr. Bioinformatician

Department

BSD PAT - Clinical Bioinformatics

About the Department

Molecular and Cytogenetic Pathology at The University of Chicago is a highly collaborative group within the Department of Pathology.

The Department of Pathology has a long and rich history of excellence in clinical service, training, and research. Our physicians and scientists are experts in a variety of subspecialties in anatomic pathology, laboratory medicine, genomics and molecular pathology, investigational pathology, and immunology. Our diverse faculty study and diagnose patient disease and medical conditions using state-of-the-art methodologies. We invite you to browse our website to learn more about our rich offerings of clinical services, education, and research. https://pathology.uchicago.edu/.

Job Summary

The Sr. Bioinformatician is a vital resource supporting the personalized oncology services of its Clinical Genomics Laboratory. This position will work in a fast-paced cutting-edge environment and will leverage state-of-the-art software and data analysis systems to deliver innovative and exciting solutions to support clinical care and translational investigation. Duties will include day-to-day clinical data management, next generation sequencing (NGS) assay development and validation efforts as well as involvement in a variety of NGS-related translational research projects.  The Sr. Bioinformatician will also assist in preparing manuscripts or grants and take the lead role on projects and with other Bioinformatics team efforts.

Responsibilities

• Ensure timely processing and review of clinical NGS data from patient samples processed in the Clinical Genomics Laboratory.

• Leading implementation of novel software and pipelines to facilitate assay development and translational science studies.

• Identification and implementation of efficiencies in existing processes and pipelines.

• Analysis, display and interpretation of genomic data to support clinical development, including creation of validation summary documentation in accordance with Clinical Laboratory Improvement Amendments (CLIA) guidelines.

• Ensuring proper maintenance, organization, and backup of clinical laboratory data on on-site high performance computing cluster systems.

• Participation in translational research studies within the Clinical Genomics Laboratory, in collaboration with GMP faculty and other investigators.  Includes experimental design, pipeline development, novel software engineering, custom data analysis, data integration, authorship and presentation.

• Mentor junior Bioinformaticians on the team.

• Assisting with pathology resident and fellow education in bioinformatics.

• Participates in creating data algorithms and specialized computer software to identify and classify components of a biological system (i.e. DNA and protein sequences).

• Applies basic application of computational tools and information technology to gather, analyze and visualize data in biology and biomedical research.

• Interprets data analysis of high throughput genomics, proteomics and genetic data.

• Plans own resources to implement or modify existing web-based bioinformatics tools.

• Develop programs to perform analyses and generate both routine and ad hoc reports.

• Guides with researchers to analyze problems, recommend technology-based solutions, or determine computational strategies.

• Designs and perform formal evaluation of informatics methods and products.

• Manipulates publicly accessible, commercial, or proprietary genomic, proteomic, or post-genomic databases.

• Performs other related work as needed.

Minimum Qualifications

Education:

Minimum requirements include a college or university degree in related field.

Work Experience:

Minimum requirements include knowledge and skills developed through 5-7 years of work experience in a related job discipline.

Certifications:

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Preferred Qualifications

Education:

• Master’s or PhD in Bioinformatics, Computational Biology, or related field.

Experience:

• Experience and proficiency in Python, R, Bash, MySQL

• Experience working in a Clinical Laboratory.

• Strong computing skills and Linux experience, with software development experience in multiple programming languages, including Python and R.

• Next generation sequencing bioinformatics knowledge, preferentially with previous cancer and clinical laboratory experience.

• Strong scientific data analysis and presentation skills.

• Strong knowledge of next generation sequencing methodology and data analysis.

• Prior experience working with large-scale datasets using high performance computing environment.

Working Conditions

• Lab environment.

• Weekend/Evening hours: Flexibility with occasional work on weekends for clinical sample processing is expected.

Application Documents

• Resume (required)

• Cover Letter (preferred)

When applying, the document(s) MUST be uploaded via the My Experience page, in the section titled Application Documents of the application.

Job Family

Research

Role Impact

Individual Contributor

Scheduled Weekly Hours

40

Drug Test Required

No

Health Screen Required

No

Motor Vehicle Record Inquiry Required

No

Pay Rate Type

Salary

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FLSA Status

Exempt

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Pay Range

$80,000.00 - $110,000.00

The included pay rate or range represents the University’s good faith estimate of the possible compensation offer for this role at the time of posting.

Benefits Eligible

Yes

The University of Chicago offers a wide range of benefits programs and resources for eligible employees, including health, retirement, and paid time off. Information about the benefit offerings can be found in the Benefits Guidebook.

Posting Statement

The University of Chicago is an equal opportunity employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender, gender identity, or expression, national or ethnic origin, shared ancestry, age, status as an individual with a disability, military or veteran status, genetic information, or other protected classes under the law. For additional information please see the University's Notice of Nondiscrimination.

 

Job seekers in need of a reasonable accommodation to complete the application process should call 773-702-5800 or submit a request via Applicant Inquiry Form.

 

All offers of employment are contingent upon a background check that includes a review of conviction history.  A conviction does not automatically preclude University employment.  Rather, the University considers conviction information on a case-by-case basis and assesses the nature of the offense, the circumstances surrounding it, the proximity in time of the conviction, and its relevance to the position.

 

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