Principal Scientist or Associate Scientist, Computational Sciences, Research

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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Scientist/Senior Scientist, Computational Chemistry in Cambridge, MA, US or Fujisawa, Kanagawa, Japan.
At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

OBJECTIVES/PURPOSE

• Work as part of a multi-disciplinary team of medicinal chemists, structural biologists, data scientists and biologists and provide computational expertise to advance drug discovery projects.
• Contribute to drug discovery efforts across various modalities including small molecules, PROTACs, RNA inhibitors, peptides, and more.
• Implement and execute innovative computational methodologies and tools such as AI, free energy, and cheminformatics approaches to support drug discovery efforts.

ACCOUNTABILITIES

• Demonstrate an understanding of computational chemistry principles and their application within a multidisciplinary drug discovery environment.
• Independently design, develop and execute research assignments, contributing to multiple projects.
• Identify, develop, validate, and implement innovative computational approaches that enhance research productivity and success.
• Provide key technical knowledge and input to project teams to drive decision-making in drug discovery projects.

Requirements:

• PhD degree in Chemistry or equivalent
• Ideally 2+ years of experience in industry
• Experience with a variety of computational tools and methodology including large-scale virtual screening, ligandability analyses, homology modeling, quantum mechanics, pharmacophore elucidation, machine learning and more against common drug discovery targets (GPCRs, Kinases etc.).
• Comprehensive experience in data mining and data analysis.
• Familiarity with organic and synthetic chemistry concepts
• Provide project teams with computational strategies to inform, influence, and prioritize designs for potency/selectivity and improve ADME/Tox endpoints.
• Contribute to the development and deployment of design and/or AI platforms to impact drug discovery.
• Familiarity with standard computational chemistry software including Schrodinger Suites, KNIME, and more.
• Proficiency in scientific scripting and programming languages including python.
• Business level of Japanese and English language proficiency

Apply now and be part of our mission to deliver Better Health and a Brighter Future to people around the world.
 

Takeda Compensation and Benefits Summary:

• Allowances: Commutation, Housing, Overtime Work etc.

• Salary Increase: Annually, Bonus Payment: Twice a year

• Working Hours: Headquarters (Osaka/ Tokyo) 9:00-17:30, Production Sites (Osaka/ Yamaguchi) 8:00-16:45, (Narita) 8:30-17:15, Research Site (Kanagawa) 9:00-17:45

• Holidays: Saturdays, Sundays, National Holidays, May Day, Year-End Holidays etc. (approx. 123 days in a year)

• Paid Leaves: Annual Paid Leave, Special Paid Leave, Sick Leave, Family Support Leave, Maternity Leave, Childcare Leave, Family Nursing Leave.

• Flexible Work Styles: Flextime, Telework

• Benefits: Social Insurance, Retirement and Corporate Pension, Employee Stock Ownership Program, etc.

Important Notice concerning working conditions:

• It is possible the job scope may change at the company’s discretion.

• It is possible the department and workplace may change at the company’s discretion.

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