Sr Scientist I, Molecular Biology

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

Purpose:

Conceive and implement novel experimental approaches to answer scientific questions. Investigate, identify, develop, and optimize new methods and techniques. Contribute to project science in area of expertise. Develop productive collaborations and communications with other groups across science disciplines. We are looking for a Sr. Scientist with a molecular biology background to join our peptide display hit generation team. This role is responsible for developing methods and processes to scale molecular biology workflows for peptide display selection (mRNA and/or Phage-Display) to many targets and screening conditions by utilizing molecular barcoding strategies, laboratory automation, and other relevant technologies. This role will also utilize our proprietary peptide microarray platform to aid in accelerating hit identification from peptide display selections.      

Responsibilities:

• Lead application of existing mRNA-Display workflows to multiple targets and screening conditions. Includes generation of peptide mRNA-Display libraries, designing and carrying out selections against therapeutic targets under multiple conditions, preparing next-generation sequencing libraries, and analyzing the resulting data.
• Lead development of processes and methods to improve efficiency in application of peptide mRNA-Display workflows to multiple targets and screening conditions. Includes utilization of molecular barcoding strategies, laboratory automation, and other relevant technologies.
• Utilize proprietary data analysis tools to organize data from multiple peptide mRNA-Display screens and analyze multiple datasets to identify pharmaceutically relevant hits.
• Routinely demonstrate scientific initiative and creativity in research or development activities.
• Highly autonomous and productive in performing laboratory research or method development, requiring only minimal direction from or interaction with supervisor.
• Formulate conclusions and design follow-on experiments based on multidisciplinary data.
• May initiate new areas of investigation that are scientifically meaningful, reliable, and can be incorporated directly into a research or development program.
• A primary author of publications, presentations, regulatory documents and/or primary inventor of patents.
• Demonstrates high proficiency across a wide range of relevant technologies.
• Maintain a high level of productivity in the lab and/or pilot plant.
• Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug and radioactive compounds, GxP compliance, and animal care where applicable.
• Direct mentorship of others.
   

Qualifications

• Bachelor’s Degree or equivalent education and typically 10 years of experience, Master’s Degree or equivalent education and typically 8 years of experience, PhD and no experience necessary.
• Possess thorough theoretical and practical understanding of own scientific discipline.
• Degree(s) should be in Molecular Biology, Biochemistry, Chemical and Biological Engineering, or other relevant fields.
• Training in molecular biology and microbiology methods for the generation and screening of large-scale molecular libraries
• Experience in peptide mRNA-display, including library design and generation, library screening, and data analysis
• Experience with generating next-generation sequencing libraries and analysis of resulting datasets
• Skills in coding for data science (e.g. Python) and/or a willingness to learn
• Experience with laboratory automation and/or molecular barcoding for scaling molecular biology workflows
• Experience in process/project management, including prioritization and scheduling of complex laboratory processes.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​​

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• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​​

• This job is eligible to participate in our short-term incentive programs. ​​

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled. 

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