Intern, Clinical Pharmacology & Quantitative Science (Project: developing PBPK models in antibody medicine)

At Genmab, we are dedicated to building extra[not]ordinary® futures, together, by developing antibody products and groundbreaking, knock-your-socks-off KYSO antibody medicines® that change lives and the future of cancer treatment and serious diseases. We strive to create, champion and maintain a global workplace where individuals’ unique contributions are valued and drive innovative solutions to meet the needs of our patients, care partners, families and employees.

Our people are compassionate, candid, and purposeful, and our business is innovative and rooted in science. We believe that being proudly authentic and determined to be our best is essential to fulfilling our purpose. Yes, our work is incredibly serious and impactful, but we have big ambitions, bring a ton of care to pursuing them, and have a lot of fun while doing so.

Does this inspire you and feel like a fit? Then we would love to have you join us!

Why Genmab

Be part of the extra[not]ordinary®: This is our unique word meaning we go way beyond what is usual; to be remarkable; proudly unique and authentic. This is your opportunity to make a profound difference with one of the world’s top companies solely dedicated to antibody therapeutics – a people-charged biotech innovation powerhouse rooted in science and inspired by patients.

Our internship program provides interns with hands-on experience and meaningful projects that directly contribute to our company’s goals. Additionally, we believe that our program offers not just a chance to learn but also the opportunity to grow, network, and play a critical role in our efforts to make a difference for patients, every single day!

 

The Role

Accurate pharmacokinetic modeling is essential in preclinical drug development, particularly for biologics like therapeutic antibodies. Physiologically based pharmacokinetic (PBPK) models play a pivotal role in predicting Target-Mediated Drug Disposition (TMDD), guiding optimal dosing strategies and ensuring therapeutic efficacy and safety. At Genmab, we leverage quantitative approaches, including PBPK modeling, to better understand the pharmacokinetics of antibody-based therapeutics and their interactions with different targets to advance drug candidates.

As an intern within the Quantitative Translational Pharmacology team at Genmab, you will contribute to PBPK modeling projects. Your responsibilities will include analyzing and integrating diverse target expression datasets, including multi-level datasets such as protein abundance, mRNA expression levels, and immunohistochemistry (IHC) scoring and quantitative immunofluorescence, to support robust PBPK model development. Understanding the localization of therapeutic targets across different tissues and organs will be a crucial component of your analysis. You will gain practical experience in data handling, quantitative modeling, and scientific communication within a dynamic biotech environment. You will gain practical experience in data handling, quantitative modeling, and scientific communication within a dynamic biotech environment.

Responsibilities

• Collecting comprehensive target expression data from public databases, proprietary resources, and multi-level datasets (protein abundance, mRNA expression, IHC scoring, quantitative immunofluorescence).
• Developing computational tools, leveraging methods such as the sigmoidal conversion approach by Sepp & Muliaditan (2024), to integrate heterogeneous datasets into accurate and standardized target concentration estimates.
• Incorporating target localization information to enhance the accuracy and relevance of PBPK model predictions.
• Validating PBPK model predictions by comparing simulated outcomes against experimentally observed preclinical pharmacokinetic data for known therapeutic targets (e.g., EGFR, HER2).
• Effectively communicate results and insights through concise reports and clear presentations.

This internship provides an opportunity to engage directly with applied quantitative modeling in drug development, offering flexibility to tailor specific project directions according to your interests and expertise!

Requirements 

• Enrolled in a Master’s program in Statistics, Biopharmaceutical Sciences, Biomedical Sciences, Drug Innovation, Pharmacy, Data Science or a related field at a University in the Netherlands.
• Experience with R programming.
• Basic knowledge of cancer biology and/or immunology.
• You have experience in, or a strong interest in learning, single-cell data analysis and antibody drug discovery.
• You enjoy working collaboratively in a multidisciplinary team.
• Excellent communication and collaboration skills in English.
• Previous programming experience, ideally with the development of your own package.

Preferred Qualifications, Capabilities, and Skills

• Knowledge of AI techniques applied to chemical compound characterization, target discovery, and single-cell data analysis.
• Experience with biomedical or chemical research datasets.
• Familiarity with immuno-oncology, gynecological cancers.
• Previous industry experience or internship in a related field.
   

General Internship Information

• Internship duration: 6-9 months.
• Start date: September 1st / October 1st.
• Location: Utrecht, Netherlands
• Hybrid schedule: at least 3 days in the office, 2 days remote per week.

What’s Next?

Help us learn about you by submitting a complete and thoughtful application, including your resume and motivation letter. Your application and resume are our first introduction to you, so please complete all relevant application questions to provide as much information as possible.

We will review each submission as quickly as possible to determine whether you meet the qualifications for the role. Due to the volume of applications, we cannot respond to inquiries regarding application status. If you advance to the next step, you will receive an invitation for further discussion. The final step includes interviews with hiring team members, after which we will communicate final decisions to all interviewed candidates.

We look forward to receiving your application and exploring the possibility of you joining our team to contribute to the advancement of antibody therapeutics!

About You

• You are genuinely passionate about our purpose

• You bring precision and excellence to all that you do

• You believe in our rooted-in-science approach to problem-solving

• You are a generous collaborator who can work in teams with a broad spectrum of backgrounds

• You take pride in enabling the best work of others on the team

• You can grapple with the unknown and be innovative

• You have experience working in a fast-growing, dynamic company (or a strong desire to)

• You work hard and are not afraid to have a little fun while you do so!

Locations

Genmab maximizes the efficiency of an agile working environment, when possible, for the betterment of employee work-life balance. Our offices are crafted as open, community-based spaces that work to connect employees while being immersed in our powerful laboratories. Whether you’re in one of our office spaces or working remotely, we thrive on connecting with each other to innovate.

About Genmab

Genmab is an international biotechnology company with a core purpose to improve the lives of patients through innovative and differentiated antibody therapeutics. For 25 years, its hard-working, innovative and collaborative team has invented next-generation antibody technology platforms and harnessed translational, quantitative and data sciences, resulting in a proprietary pipeline including bispecific T-cell engagers, antibody-drug conjugates, next-generation immune checkpoint modulators and effector function-enhanced antibodies. By 2030, Genmab’s vision is to transform the lives of people with cancer and other serious diseases with Knock-Your-Socks-Off (KYSO®) antibody medicines.

Established in 1999, Genmab is headquartered in Copenhagen, Denmark with international presence across North America, Europe and Asia Pacific. For more information, please visit Genmab.com and follow us on LinkedIn and X.

Genmab is committed to protecting your personal data and privacy. Please see our privacy policy for handling your data in connection with your application on our website Job Applicant Privacy Notice (genmab.com).

Please note that if you are applying for a position in the Netherlands, Genmab’s policy for all permanently budgeted hires in NL is initially to offer a fixed-term employment contract for a year, if the employee performs well and if the business conditions do not change, renewal for an indefinite term may be considered after the contract.