Scientist, Proteomics

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Overview:

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.

Position Summary:

For our discovery proteomics group at Lilly Oncology in South San Francsico, we are looking for a new team member who is enthusiastic about performing discovery proteomics in spatially defined compartments of tissues and/or cultured cells.

This position presents an opportunity to work within a dynamic discovery research team dedicated to analyzing proteomic biology for genetically defined oncology targets. The ideal candidate is someone who is confident working with mass spectrometry techniques, enjoys technical and biological challenges and is familiar with sample preparation for proteomic analysis such as tissue preparation for protein characterization, biophysical experiments, laboratory automation and handling data analysis statistics of results. 

The qualified candidate will have experience with basic chemistry/biology laboratory practices, is knowledgeable with mass spectrometry and other methods and passionate about working in a growing dynamic group focused on discovery oncology research. 

The successful candidate will work as part of a collaborative team of scientists with expertise in protein production, cell culture, chemistry, biochemistry, structure, and biophysics, supporting hit-to-lead and lead-ID phases of our oncology drug programs. The candidate will have opportunities to expand their knowledge of cutting-edge techniques, working with state-of-the-art instrumentation and to learn and further develop existing technical expertise in protein biochemical and biophysical characterization.

Responsibilities:

• Preparation of cells and tissues for immunohistochemical staining and subsequent isolation via laser-microdissection.
• Knowledge and experience with quality assurance related to all the following: specimen fixation, processing, microtomy; reagent selection, preparation, storage, disposal; method selection, validation, documentation; quality control; safety.
• Purification of proteins from a variety of biological samples such as cultured cells or tissue preparations to support biophysical/biochemical studies.
• Collaborate with colleagues throughout the company to ensure timely delivery of assay data. Communicate and present data to a wider audience of the team and outside collaborators.
• Adapt to highly dynamic project priorities, with diligent and rapid communication of scientific results and insights to the team.
• Participate in discussions with vendors for outsourced services and studies.
• Learn and develop technical expertise in protein biochemical and biophysical characterization.
• Develop and continually advance one’s knowledge base on genetically targeted drugs and structure-based drug design.

Basic Requirements:

• BS with 4+ years of relevant experience (academic research setting and/or industry)
• General knowledge of mass spectrometry and familiarity with current instrumentation, preferably with Thermo Scientific or Bruker instruments.
• Ability to use cryostat, microtome, tissue processor, and stainer including immunohistochemistry platform.
• Hands-on experience with widefield microscopy and laser-capture microdissection.
• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.

Additional Preferences:

• Highly organized with excellent analytical, documentation and multi-tasking skills.
• Committed to staying current with the latest scientific breakthroughs in structure-based drug design and structural biology.
• Knowledge in statistical computation like basic skills in R or Python would be ideal.
• Experience in identification of spatially defined areas of interest in tissues and cultured cells via various immunohistochemical methods is a plus.
• Expertise in other methods of enzymology or biophysical characterization and structural biology is a plus.

Additional Information:

Physical Demands/Travel:

The physical demands of this job are consistent with a lab environment.  

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work is in a Laboratory environment.  

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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