Senior Principal Scientist, Computational Pathobiologist

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Nonclinical Safety

Job Category:

Scientific/Technology

All Job Posting Locations:

La Jolla, California, United States of America, Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine:

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Senior Principal Scientist, Computational Pathobiologist to be located in Spring House, PA or La Jolla, CA.

Purpose:

The Pathobiology Department, Preclinical Sciences and Translational Safety (PSTS), is seeking a highly motivated Senior Principal Scientist to lead the delivery of transformative data analytics and capabilities that will drive diagnostic efficiency, holistic data interpretations and robust mechanistic insights. Pathobiology is a team of toxicologic pathologists, toxicologic clinical pathologists, immunotoxicologists, molecular and histopathology scientists and clinical pathology & safety biomarker scientists responsible for delivering end to end on the PSTS portfolio (efficacy-to-safety, Discovery through Post-Marketing) across all J&J modalities and therapeutic areas.

The Senior Principal Scientist will advance the digital transformation of Pathobiology by deploying pathobiology data solutions across Pathobiology functions to interrogate, analyze and interpret multimodal nonclinical safety data, enabling the integration and interpretation of study data, meta-analyses, mechanistically founded hypothesis generation and predictive modeling. Success in this role requires strong matrix leadership skills, effective stakeholder management, and a breadth of pathobiology and computational knowledge to translate key concerns and portfolio needs into meaningful data science questions and investigating those using relevant data analytics and visualization techniques. The candidate is proactive, intellectually curious and will thrive in a dynamic, multidisciplinary and collaborative environment. This role is expected to provide support across all Pathobiology functions and reports to the Global Head of Clinical Pathology & Safety Biomarkers (CPSB) with a matrix-based reporting line to the Pathobiology Operations Lead.

You will be responsible for:

• partnering with Pathobiology stakeholders (Target Pathology, Clinical Pathology & Safety Biomarkers, Immunotoxicology, Investigative Pathobiology), under the guidance of the Pathobiology Operations Lead, to understand, prioritize and implement Pathobiology data needs and use cases, including ensuring FAIR Pathobiology metadata.
• successfully collaborating and delivering results in a matrixed environment across PSTS functions (including BDDS, TPPIT, SIS and NCSS Nonclinical Safety/Toxicology stakeholders) and DPDS (IT and Data Science) to assess data landscape and develops strategy, implementation roadmaps and action plans.
• independently developing solutions for Pathobiology data search, interpretation, reporting and communication to stakeholders; deploy relevant data transformations, visualizations, ​ummaries and analytics; deploy quality control measures to ensure accuracy and completeness of analyses and solutions; develop and implements statistical and machine learning models applied to multimodal pathobiology data.
• serving as a subject matter expert in Pathobiology data science, capable of recommending the optimal solution and leading development and implementation. Provide expertise and mentorship on Pathobiology data science methodologies. Provide scientific leadership in data analytics, fostering a data-driven culture, and applying innovative approaches.
• interpreting and communicating outcomes of analyses with an appropriate level of independence in report writing and PowerPoint presentations. Collaborate, present and communicate project-related deliverables and findings in multidisciplinary PSTS team meetings.

Education:

• A minimum of a Master’s degree in Biology or a Computational Science, (Computer Science, Biostatistics, Engineering, or Data Science or related field) with experience in programming and data science is required
• A PhD in Biology or a Computational Science, (Computer Science, Biostatistics, Engineering, or Data Science or related field) with experience in programming and data science is highly preferred

Required

• a minimum of 8 years of Data Science experience in an industry or academic setting post-degree in positions of increasing responsibility is required
• Good knowledge of SAS required
• Proficiency in programming (e.g. Python, R, SQL, Javascript) and experience with Cloud Platforms (e.g. GCP, Azure, AWS) is required
• Skill in data visualization and dashboarding tools (e.g. Spotfire, PowerBI, R-Shiny) is required
• Proficiency in the use of statistical models and AI (e.g. multivariate linear regression, cluster algorithms, decision trees, logistic regression, Principal Component Analysis [PCA], machine learning [supervised and unsupervised], Bayesian Methods, Neural Networks) is required
• Knowledge of medical terminology and familiarity with biological research is required

Preferred:

• Experience in the disciplines of Biology, Biotechnology, Immunology, Pathology, In Vitro Diagnostic, or Health Care industries required. Understanding of pathology and immunology-related data (e.g. molecular pathology, image analysis, biomarkers PCR, flow cytometry and immunoassays) is preferred
• Proficiency in healthcare informatics (SNOMED, CPT, HL7) is preferred

The anticipated base pay range for this position is $137,000 - $235,750

The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/performance year. Bonuses are awarded at the Company’s discretion on an individual basis.

• Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.
• Employees may be eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).
• This position is eligible to participate in the Company’s long-term incentive program.
• Employees are eligible for the following time off benefits:

– Vacation – up to 120 hours per calendar year

– Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington – up to 56 hours per calendar year

– Holiday pay, including Floating Holidays – up to 13 days per calendar year

– Work, Personal and Family Time - up to 40 hours per calendar year

Additional information can be found through the link below.

For additional general information on Company benefits, please go to:

• https://www.careers.jnj.com/employee-benefits

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (ra-employeehealthsup@its.jnj.com) or contact AskGS to be directed to your accommodation resource.

The anticipated base pay range for this position is :

$137,000 - $235,750

Additional Description for Pay Transparency: