Postdoctoral Fellow in computational modelling of NeuroImmune Mechanisms of Neurodegeneration (Open Targets)
Hinxton, United Kingdom
European Molecular Biology Laboratory (EMBL)
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Your role
As a Postdoctoral Fellow on the NeuroImmune Open Targets project, you will develop and apply integrative computational pipelines to dissect immune-cell phenotypes and cellācell interactions across Alzheimerās, Parkinsonās, and Amyotrophic lateral sclerosis patient tissues and matched induced pluripotent stem cells models.
Your group
Saez-Rodriguez Research Group in collaboration with Open-Targets
Your supervisor
Julio Saez-Rodriguez
You will
Analyze large-scale single-cell and spatial transcriptomics datasets from human brain samples to identify shared multi-cellular pathological features
Build and apply statistical and machine-learning methods to infer cell-cell signaling networks and causal drivers
Develop pipelines to compare patient-derived data with hiPSC-derived models, identifying recapitulated phenotypes and candidate intervention targets
Write up results for high-impact publications and present at international conferences
Contribute to collaborative grant proposals and supervise junior team members
You have
PhD in a relevant field with evidence of productive computational research
Hands-on experience with single-cell and spatial data analysis workflows
Strong statistical modelling and coding proficiency in R and/or Python
Ability to translate complex computational results into biological insights
A track record of (co)first-author publications and effective science communication
You may also have
Demonstrated experience with single-cell and/or spatial transcriptomics data analysis
Experience with network biology computational tools
Knowledge of immunology, especially microglial and T-cell biology
Background in neurodegenerative disease biology (e.g., AD, PD, ALS) and/or familiarity with polygenic risk score analyses or rare-variant genetics would also be useful
Contract length: 2 year fixed term contract, with possibility for renewal to a maximum of 5 years.
Salary: Year 1 Stipend at rate of £3,307 per month after tax but excluding pension and insurance contributions.
How to Apply
Please submit:
1. A tailored cover letter highlighting your fit to the project and pointing to your code repository (e.g., GitHub)
2. Your CV with a list of publications
3. Contact details for three referees
Non-specific applications without a tailored expression of interest (cover letter) will not be considered.
Professional development support
The EMBL Fellowsā Career Service provides support and guidance to predoctoral and postdoctoral fellows across all six EMBLās sites.
Working with a dedicated Careers Advisor, this invaluable service will help you to take informed decisions about your career planning both in the short and longer term. Whether your main interest is pursuing a career path in academia, exploring opportunities in industry or exploring an independent venture, the EMBL Fellowsā Career Service with provide you with a portfolio of activities and resources to help you.
To find out more please visit - EMBL-fellows-career-service
Why join us
Join a culture of innovationĀ
We are located on the Wellcome Genome Campus, alongside other prominent research and biotech organisations, and surrounded by beautiful Cambridgeshire countryside. This is a highly collaborative and inclusive community where our employees enjoy a relaxed atmosphere. We are committed to ensuring our employees feel valued, supported and empowered to reach their professional potential.Ā
Enjoy lots of employee benefits:
Financial incentives:Ā Monthly family and child allowances, generous stipend reviewed yearly, pension scheme, death benefit and unemployment insurances
Flexible working arrangements including hybrid working patternsĀ
Private medical insuranceĀ for you and your immediate familyĀ
Generous time off:Ā 30 days annual leave per year in addition to public holidays
Campus life:Ā Free shuttle bus to and from work, on-site library, subsidised on-site gym and cafeteria, casual dress code, extensive sports and social club activities (on campus and remotely)
Family benefits: On-site nursery (Heidelberg & Hinxton), 10 days of child sick leave, paid maternity & parental leave, holiday clubs on campus and monthly family and child allowances
Benefits for non-residents:Ā Visa and financial support to relocate if you're overseas
What else you need to know
International applicants: We recruit internationally and successful candidates are offered visa exemptions. Read more on our page for international applicants.Ā
Diversity and inclusion: At EMBL, we strongly believe that inclusive and diverse teams benefit from higher levels of innovation and creative thought. We encourage applications from women, LGBTQ+ & individuals from all nationalities.Ā
Job location: All our fellowships are based on-site (for at least part of each week). If you are living overseas, you will receive a generous relocation package to support you.Ā
EMBL is a signatory of DORA. Find out how we apply DORA principles to our recruitment and performance assessment processes here.
Watch this video to find out what it's like to be a Postdoc at EMBL-EBI.
How to apply: To apply please submit a cover letter and a CV through our online system. Applications will close at 23:59 CET on the date shown below. We aim to provide a response within two weeks after the closing date below.
Closing Date
27/07/2025
Ā
* Salary range is an estimate based on our AI, ML, Data Science Salary Index š°
Tags: Biology Data analysis GitHub PhD Pipelines Postdoc Python R Research Statistics STEM
Perks/benefits: Career development Conferences Fitness / gym Flex hours Flex vacation Health care Medical leave Parental leave Relocation support
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