Postdoctoral Fellow-Vaccine-induced Immune Durability
USA - New York - Pearl River, United States
Full Time Mid-level / Intermediate USD 62K - 104K
Postdoctoral Fellow Immune Durability
Why Patients Need You
Pfizerās purpose is to deliver breakthroughs that change patientsā lives. Research and Development (R&D) is at the heart of fulfilling Pfizerās purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. As a post-doctoral scientist in the Vaccines organization, you will apply cutting edge technologies to accelerate and bring the best-in-class and safe medicines to patients around the world.
What You Will Achieve
As a Postdoctoral Fellow, you will be part of the Cellular Mediated Immunity (CMI) & Immune Profiling group within the Viral Vaccines team. You will collaborate with multi-disciplinary and talented scientists towards development of assays to predict immune response durability prior to human clinical trials and investigate the mechanisms of early vaccine-elicited signals related to antibody longevity. Your goals will be:
Establish in vivo systems using mice and/or non-human primates (NHPs) as models to test different vaccine platforms and candidates to investigate biomarkers of antibody durability. Ā
Analyze transcriptomic data to establish correlations between gene expression signatures and immunological readouts.
Test mechanistic hypothesis in in vitro experiments and/or murine interventions to further define the mechanisms of plasma cell and plasmablast longevity.
Your strong foundation in immunology, molecular biology and immune profiling techniques including bulk and single cell RNA sequencing, as well as in vitro cell culture techniques, and related principles and concepts will enable you to assess the assigned tasks and design approaches that involve direct application of your knowledge.
It is your dedication, innovative ideas, and focus that will help in making Pfizer ready to achieve new milestones and help combating infectious diseases across the globe.
How You Will Achieve It
Driving innovation, independent thinking, literature research, problem solving, and meticulous design, execution and interpretation of experiments under minimal supervision.
Collaborating with multi-disciplinary, investigative Vaccines teams and working closely with the In Vivo, Serology and Data Science teams assessing immunological readouts using various platforms (including MultiOmics).
Work with mentors, develop and apply complex assays for exploring translatable gene expression signatures through bulk and single cell RNA sequencing that can serve as biomarkers.
Present the research work at various internal and external meetings and conferences and publish in relevant peer-reviewed journals.
Contribute to building a culture that embraces scientific excellence, urgency, partnerships with key stakeholders, continuous learning and improvement, increasing technical skill base and immunology expertise.
Ensure all tasks and responsibilities are carried out according to scientific, ethical and regulatory standards.
Qualifications
Must-Have
Ph.D. in Immunology, Virology, Molecular Biology, Computational Immunology or related fields. No more than 2 years of post-degree experience.
Demonstrated experience in diverse cellular, biochemical and molecular laboratory techniques with strong background in immunology.
Experience using flow cytometry techniques as well as flow cytometry analysis software such as FlowJo and/or OMIQ, as well as GraphPad, Excel analysis software.
Knowledge and hands-on experience in sequencing techniques including RNA isolation, library preparation and RNA sequencing.
Experience in analyzing āomicsā data (genomics, transcriptomics, single cell RNAseq, etc.) for biomedical research.
Well organized, self-motivated, team-oriented with ability to multitask with high attention to detail.
Strong collaborative spirit and communication skills.
Successful record of scientific accomplishments as indicated by scientific publications and/or presentations. At least one first-author publication in peer-reviewed scientific journals.
Willingness to make a minimum 2-year commitment.
Nice-to-Have
Working knowledge of programming languages such as R or Python.
Experience with animal models including NHPs in desirable but not required.
Hands-on knowledge and experience with single-cell RNA sequencing platforms (10x, inDrop, Drop-Seq, etc.)Ā
OTHER JOB DETAILS
Must have work authorization in the US.
Work Location Assignment:Ā On Premise
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations.Ā These laws and regulations require Pfizer to provide government agencies with information such as a health care providerās name, address and the type of payments or other value received, generally for public disclosure.Ā Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.Ā Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government.Ā If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.Ā Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Ā Pfizer is an E-Verify employer. Ā This position requires permanent work authorization in the United States.
Research and Development#LI-PFETags: Biology Excel Python R R&D Research
Perks/benefits: Career development Conferences Health care Medical leave Parental leave Relocation support Salary bonus
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