Bioinformatics Scientist

(ID: 2025-0442)

Axle is a bioscience and information technology company that offers advancements in translational research, biomedical informatics, and data science applications to research centers and healthcare organizations around the globe. With experts in biomedical science, software engineering, and program management, we focus on developing and applying research tools and techniques to empower decision-making and accelerate research discoveries. We work with some of the top research organizations and facilities in the country including multiple institutes at the National Institutes of Health (NIH).

Benefits:

• 100% Medical, Dental & Vision Coverage for Employees
• Paid Time Off (Including Holidays)
• Employee Referral Bonus
• 401K Match
• Tuition reimbursement and professional development opportunities
• Flexible Spending Accounts:
  • Healthcare (FSA)
  • Parking Reimbursement Account (PRK)
  • Dependent Care Assistant Program (DCAP)
  • Transportation Reimbursement Account (TRN)

Overview

Axle is looking to add a driven, flexible, organized, and meticulous Bioinformatics Scientist to our dynamic team. The Contractor(s) shall provide services in support of the overall functions of the Vaccine Research Center (VRC), Structural Bioinformatics Core (SBC).

 

Technical Requirements:

• Implement and/or run software(s) for:

  • Structural analysis of HIV-1 antibody/antigen complexes

  • Antibody resistance analysis for pathogens with high sequence diversity

  • Structure-based design to improve antibody potency and breadth for HIV-1 and other pathogens

  • Structure-based design of immunogens for HIV-1 and other pathogens

  • Statistical analysis of VRC immunization studies for HIV-1 and other pathogens

  • Other bioinformatics analysis to assist the missions of Structural Biology and Structural Bioinformatics Core Sections

• Express, purify, and characterize protein designs from the Structural Bioinformatics Core Section

• Determine atomic-level structures for protein designs from the Structural Bioinformatics Core Section

• Assist with creating figures, writing, and proof reading scientific manuscripts.

 

Specific Qualifications:

• Bachelor degree in Bioinformatics, Biochemistry, or a related discipline is required.

• Minimum of one year of experience with HIV-1 fusion peptide-directed antibody research

• Prior experience in Python or Perl

• Prior experience with protein modeling programs (e.g. PHENIX, ccp4, Coot, etc.)

• Prior experience with protein visualization software (e.g PyMoL or Chimera)

• Prior experience in protein purification

• Prior experience with protein binding assays, such as ELISA and bio-layer interferometry

• Prior experience in X-ray crystallography

The diversity of Axle’s employees is a tremendous asset. We are firmly committed to providing equal opportunity in all aspects of employment and will not tolerate any illegal discrimination or harassment-based age, race, gender, religion, national origin, disability, marital status, covered veteran status, sexual orientation, status with respect to public assistance, and other characteristics protected under state, federal, or local law and to deter those who aid, abet, or induce discrimination or coerce others to discriminate.

Accessibility: If you need an accommodation as part of the employment process please contact: careers@axleinfo.com

Disclaimer: The above description is meant to illustrate the general nature of work and level of effort being performed by individual’s assigned to this position or job description. This is not restricted as a complete list of all skills, responsibilities, duties, and/or assignments required. Individuals may be required to perform duties outside of their position, job description or responsibilities as needed.

This role has a market-competitive salary with an anticipated base compensation range listed below. Actual salaries will vary depending on a candidate’s experience, qualifications, skills, and location.

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Salary Range$70,000—$80,000 USD