Senior Director, RWD Insights

GeneDx (Nasdaq: WGS) delivers personalized and actionable health insights to inform diagnosis, direct treatment, and improve drug discovery. The company is uniquely positioned to accelerate the use of genomic and large-scale clinical information to enable precision medicine as the standard of care. GeneDx is at the forefront of transforming healthcare through its industry-leading exome and genome testing and interpretation services, fueled by the world’s largest, rare disease data sets. For more information, please visit www.genedx.com.

The mission of the Innovation Lab is to increase the diagnostic yield of our exome and genome products and reduce the time to diagnosis for patients with an undiagnosed hereditary disease. The big goal is to deliver personalized and actionable health insights to every person who orders a genetic test from GeneDx. Achievement of our goals will require a culture of innovation, where creativity, experimentation, and the pursuit of new ideas are encouraged and embraced. Individuals are empowered to think critically, take risks, and challenge the status quo, to generate breakthrough solutions and drive positive change.

Summary:

We are seeking an experienced Senior Director of Real-World Data Insights to lead the development and execution of strategies that harness real-world data to generate insights into genetic disease onset, progression and treatments. This leader will play a critical role shaping our approach for collection and aggregation of clinicogenomic data and work closely with product and commercial leaders to grow pharma partnership business through the development of new tools and services

Key Responsibilities:

• Strategic Leadership:
  • Define and lead the RWD insights strategy aligned with organizational goals.
  • Partner with cross-functional leaders in Product, Commercial, Clinical Research and Medical Affairs to identify high-impact opportunities for RWD applications.
• Data & Analytics Oversight:
  • Oversee the acquisition, integration, and governance of diverse real-world data sources (e.g., EHRs, claims, registries, patient-reported outcomes).
  • Lead the design and execution of advanced analytics, including predictive modeling, machine learning, and causal inference techniques.
• Insight Generation:
  • Translate complex data into clear, actionable insights that inform data products and partnerships.
  • Drive the development of dashboards, reports, and visualizations to communicate findings to stakeholders.
• Team Leadership:
  • Build, mentor, and manage a high-performing team of data scientists, epidemiologists, and analysts.
  • Foster a culture of innovation, collaboration, and continuous learning.
• External Engagement:
  • Represent the organization in external collaborations, conferences, and publications.
  • Build partnerships with academic institutions, data vendors, and regulatory bodies.

Education, Experience, and Skills:

• Advanced degree (PhD, MD, MPH, MS) in Epidemiology, Biostatistics, Data Science, Health Economics, or a related field.
• 10+ years of experience in real-world data, real-world evidence, or related fields within life sciences or healthcare.
• Proven track record of leading cross-functional teams and delivering impactful insights from complex datasets.
• Deep understanding of healthcare data sources, regulatory requirements, and evidence standards.
• Strong communication skills with the ability to influence senior stakeholders and translate technical findings into business value.
• Experience with data science tools (e.g., Python, R, SQL) and platforms (e.g., Databricks, Snowflake).
• Familiarity with regulatory guidance on RWE (e.g., FDA, EMA).
• Experience in therapeutic areas such as oncology, immunology, or rare diseases is a plus.

Physical Demands:

• Ability to stand, walk, and sit for extended periods.

Work Environment:

• Fully Remote

#LI-REMOTE

Pay Transparency, Budgeted Range$220,396—$275,495 USD

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Science - Minded, Patient - Focused. 

At GeneDx, we create, follow, and are informed by cutting-edge science. With over 20 years of expertise in diagnosing rare disorders and diseases, and pioneering work in the identification of new disease-causing genes, our commitment to genetic disease detection, discovery, and diagnosis is based on sound science and is focused on enhancing patient care.

Experts in what matters most. 

With hundreds of genetic counselors, MD/PhD scientists, and clinical and molecular genomics specialists on staff, we are the industry’s genetic testing experts and proud of it. We share the same goal as healthcare providers, patients, and families: to provide clear, accurate, and meaningful answers we all can trust.

SEQUENCING HAS THE POWER TO SOLVE DIAGNOSTIC CHALLENGES.

From sequencing to reporting and beyond, our technical and clinical experts are providing guidance every step of the way:

TECHNICAL EXPERTISE

• High-quality testing: Our laboratory is CLIA certified and CAP accredited and most of our tests are also New York State approved.
• Advanced detection: By interrogating genes for complex variants, we can identify the underlying causes of conditions that may otherwise be missed.

CLINICAL EXPERTISE

• Thorough analysis: We classify variants according to our custom adaptation of the most recent guidelines. We then leverage our rich internal database for additional interpretation evidence.
• Customized care: Our experts review all test results and write reports in a clear, concise, and personalized way. We also include information for research studies in specific clinical situations.
• Impactful discovery: Our researchers continue working to find answers even after testing is complete. Through both internal research efforts and global collaborations, we have identified and published hundreds of new disease-gene relationships and developed novel tools for genomic data analysis. These efforts ultimately deliver more diagnostic findings to individuals.

Learn more About Us here.

Our Culture

At GeneDx, we are dedicated to cultivating an environment where creativity and innovation thrive. We believe in the power of community and collaboration, where diverse perspectives are embraced, and every voice contributes to our shared success. Our team is a vibrant mix of professionals who challenge and support each other in equal measure, fostering growth both personally and professionally. When you join us, you're not just taking on a job—you're joining a movement. A movement that champions curiosity, embraces change, and believes in making an impact, one patient at a time. Cultural principles we live by:  

• Be bold in our vision & brave in our execution. 
• Communicate directly, with empathy. 
• Do what we say we're going to do.  
• Be adaptable to change.  
• Operate with a bias for action.    

Benefits include:

• Paid Time Off (PTO)
• Health, Dental, Vision and Life insurance
• 401k Retirement Savings Plan
• Employee Discounts
• Voluntary benefits

GeneDx is an Equal Opportunity Employer.

All privacy policy information can be found here.