Screening Research Associate

What if…you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability?

Prologue Medicines is dedicated to transforming drug discovery by leveraging deep biological insights and cutting-edge scientific innovations. Our mission is to deliver breakthrough therapies that address critical unmet medical needs. As part of our dynamic and collaborative team, you will have the opportunity to impact human health on a global scale.

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies, Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

Position Overview:

Job Summary:

We are seeking a highly motivated and detail-oriented Lab Automation High-Throughput Screening (HTS) Associate to join our research and development team. The HTS Associate will play a critical role in supporting drug discovery and other scientific research projects by performing high-throughput screening assays using automated laboratory systems. The ideal candidate will have experience in laboratory automation, an understanding of assay development, and a passion for scientific innovation.

Key Responsibilities:

High-Throughput Screening (HTS)

• Execute routine weekly high-throughput screening assays using automated systems.
• Set up, run, and troubleshoot HTS instruments and robotic platforms.
• Ensure accurate data collection and documentation during the screening processes.

Lab Automation:

• Program, calibrate, and maintain liquid handlers, plate readers, and other automated equipment.
• Develop and maintain automated workflows to enhance efficiency and throughput in the lab.

Data Management:

• Perform data analysis, quality control, and validation of screening results
• Collaborate with bioinformatics and data science teams to ensure proper data integration and interpretation.

Collaboration:

• Work closely with scientists, project leaders, and cross-functional teams to ensure the successful execution of HTS campaigns.
• Assist in the development and adaptation of new protocols to meet project-specific needs.

Compliance and Safety:

• Adhere to laboratory safety protocols, standard operating procedures (SOPs), and industry best practices.
• Ensure compliance with regulatory standards and internal quality control measures

Qualifications:

Education:

• Bachelor's degree in biology, Chemistry, Biochemistry, biomedical engineering, or in a related field
• Master’s degree or relevant certification in laboratory automation or related field is a plus.

Experience:

•   2+ years of experience in a laboratory setting with hands-on experience in high-throughput screening or lab automation.
• Familiarity with automated systems such as liquid handlers, plate readers, or robotic platforms.
• Experience in assay development and validation in an industrial or academic setting is highly desirable.

 Skills and Competencies:

•   Strong technical skills in lab automation and HTS instrumentation.
• Familiarity with laboratory information management systems (LIMS) and data analysis tools.
• Excellent problem-solving and troubleshooting skills.
• Strong attention to detail, organizational, and time management abilities.
• Ability to work both independently and as part of a team in a fast-paced start-up environment

Preferred Qualifications:

• Experience with ELISA-based, cell-based assays, biochemical assays, or molecular screening methods.
• Knowledge of programming and scripting languages for automation (e.g., Python, R, or similar).
• Familiarity with assay optimization techniques and statistical analysis software (e.g., GraphPad, Prism).
• Prior experience using electronic laboratory notebooks (e.g. Benchling)

Working Conditions:

• This role will primarily involve working in a laboratory setting with standard lab equipment.
• Occasional lifting of lab equipment (up to 25 lbs) may be required.
• May involve exposure to chemicals or biological agents, requiring proper use of PPE (personal protective equipment).

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.