Clinical Bioinformatician

Department:

60470 IL ACL Laboratories - Central Lab: Molecular

Status:

Full time

Benefits Eligible:

Yes

Hours Per Week:

40

Schedule Details/Additional Information:

Full-time day shift hours: ON-SITE POSITION Monday - Friday 9:00 a.m. - 5:30 p.m.

MAJOR RESPONSIBILTIES

• Work closely and independently, through regular communication with bioinformatics teammates to develop bioinformatics packages for somatic and germline targeted genes sequencing, exhibiting good code design and development practices.  

• Analyze and interpret NGS data from various sequencing platforms (e.g., Illumina, Ion Torrent) for clinical applications such as hereditary disease diagnostics, cancer genomics, and solid tumor mutation detection. 

• Develop, optimize and operationalize bioinformatics pipelines for tasks like variant calling, copy number variation (CNV) detection, structural variant analysis, and gene expression profiling. 

• Work closely with clinical laboratory staff, pathologists, directors, and researchers to translate bioinformatics analyses into actionable clinical insights. Communicate complex bioinformatics concepts and results to non-technical stakeholders in a clear and effective manner. 

• Assess data analysis workflows to identify opportunities for automation of analysis, reporting, and quality control (QC). Implement improvements in collaboration with laboratory leadership. 

• Ensure all bioinformatics workflows and analyses comply with clinical laboratory regulations and standards (e.g., CLIA, CAP). Lead the validation and verification of bioinformatic systems, including modifications, upgrades, and other changes. 

• Develop and implement bioinformatics policies and practices that adhere to CLIA, CAP, CDC, OSHA, AABB, and FDA guidelines. Oversee CAP bioinformatics surveys and ensure compliance with CAP inspections. Monitor regulatory changes and update policies accordingly. 

• Ensure the implementation of effective quality assurance and quality control programs, integrating with related committees and processes to maintain high standards. 

MINIMUM EDUCATION AND EXPERIENCE REQUIRED

• License/Registration/Certification required: n/a

• Education required: Ph.D. in Bioinformatics, Statistics, Computer Science, data science or a related field and 0-2+ years of bioinformatics experience OR

• Master’s degree with 3+ years of experience OR

• Bachelor’s degree with 5+ years of experience. 

• Experience required: Typically requires 2 years of experience with Linux-based or cloud computing environments.  Proficiency in Python, R for developing somatic and germline analysis pipelines, with experience managing the codebase using Git. Proven experience in NGS data analysis, variant detection, and annotation. 

KNOLWEDGE, SKILLS AND ABILITIES REQUIRED

• Familiar with the basic of genomics, genetics or molecular and cell biology. 

• Proficiency in Python, R, Bash, or similar programming/scripting languages. 

• Experience with high-performance computing (HPC) and cloud platforms is preferred. 

• Ability to write custom code for constructing analysis pipelines and manipulating sequence data. 

• Familiarity with cancer genomics, liquid biopsy, or hereditary disease testing preferred. 

• Experience with machine learning applications in bioinformatics preferred. 

• Demonstrated organizational ability, attention to detail, and accuracy. 

• Effective written and verbal communication skills and ability to build rapport and relate to all people. 

• Ability to work in a fast-paced environment and to handle multiple tasks simultaneously. 

• Excel with working independently, troubleshooting problems, and providing solutions.  

• Ability to speak effectively and present material to be understood by a diverse group of individuals. 

• Maintains patient confidentiality in and out of the workplace. 

PHYSICAL REQUIREMENTS AND WORKING CONDITIONS

• Operates all equipment necessary to successfully perform all job responsibilities. 

• Must have fine motor skills and manual dexterity. 

• Frequently lifts to 10 lbs. Occasionally lifts to 50 lbs. 

• Must be able to sit, stand, walk, and bend much of the workday. 

• May be exposed to mechanical, electrical, chemical, radioactive and/or infectious agents. 

• Will be exposed to human blood, tissue, and body fluids. 

• Must wear appropriate Personal Protective Equipment (PPE) as needed. 
  
   

This job description indicates the general nature and level of work expected of the incumbent. It is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities required of the incumbent. Incumbent may be required to perform other related duties.

About Advocate Health 

Advocate Health is the third-largest nonprofit, integrated health system in the United States, created from the combination of Advocate Aurora Health and Atrium Health. Providing care under the names Advocate Health Care in Illinois; Atrium Health in the Carolinas, Georgia and Alabama; and Aurora Health Care in Wisconsin, Advocate Health is a national leader in clinical innovation, health outcomes, consumer experience and value-based care. Headquartered in Charlotte, North Carolina, Advocate Health services nearly 6 million patients and is engaged in hundreds of clinical trials and research studies, with Wake Forest University School of Medicine serving as the academic core of the enterprise. It is nationally recognized for its expertise in cardiology, neurosciences, oncology, pediatrics and rehabilitation, as well as organ transplants, burn treatments and specialized musculoskeletal programs. Advocate Health employs 155,000 teammates across 69 hospitals and over 1,000 care locations, and offers one of the nation’s largest graduate medical education programs with over 2,000 residents and fellows across more than 200 programs. Committed to providing equitable care for all, Advocate Health provides more than $6 billion in annual community benefits.