NGS Bioinformatician

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

NGS Bioinformatician

At Lilly, we unite caring with discovery to make life better for people around the world. The Lilly Biotechnology Discovery Research Center (BioTDR) builds on more than 25 years of experience, consistently advancing life-changing biotherapeutics. Within BioTDR, our computational science team is dedicated to applying cutting-edge computational strategies to develop next-generation biologics that address unmet medical needs. By integrating bioinformatics, machine learning, artificial intelligence, and physics-based modeling, we innovate in the discovery process, tackling complex challenges and advancing solutions for otherwise intractable targets.

We are seeking a highly skilled next-generation sequencing (NGS) data scientist and bioinformatician to join our bioinformatics core function and accelerate the discovery of novel biologics. This role requires deep expertise in NGS data analysis. Additionally, the candidate should be experienced in extracting, analyzing, and extrapolating information from small to large datasets, as well as in building new sequence pools based on project needs and insights gained. The ideal candidate should be proactive, organized, flexible, quickly assimilate new information, and team goal oriented.  

Primary Responsibilities:

• Support Lilly research teams and projects with NGS data analysis including antibodies, proteins, single-cell RNA, peptides, and beyond. Deliver processed results with good quality in a timely manner. 
• Develop new workflows for different types of sequencing results such as bulk NGS, 10x Genomics, PacBio and Nanopore, based on project needs.     
• Collaborate with members from the computational science team and technology team to design and deliver customized antibody/VHH/mini-protein libraries.
• Create data analysis and visualization methods to interpretate results, inspire and enable data-driven AI/ML based drug discovery.
• Work with Lilly data capture team members, properly manage raw and processed data in efficient and convenient ways.
• Bring up new ideas to best utilize internal and public sequence database for new applications.

Basic Qualifications:

• Ph.D. in bioinformatics, computational biology, or similar field with a minimum of 3 years relevant experience in a Biotech/Pharmaceutical company.
• Proficiency in essential bioinformatics software and scripting languages (e.g., Python, R, Perl etc.). 

Additional Skills and Preferences:

• Thorough knowledge of modern sequencing technique procedures (Sanger, NGS, 10x Genomics, PacBio, Nanopore), with extensive experience in independent data processing. 
• Highly experienced with various NGS data processing tools, including quality control, trimming and filtering, alignment, assembly, annotation and visualization etc. Understand the differences between these tools and their optimal use cases.
• Familiar with coding packages to number, align and annotate antibody or related biologics sequences. 
• Sophisticated in data visualization and presenting results in statistical and scientific formats.
• Well experienced in customizing and coding to build new sequencing data analysis workflows from scratch.
• Experienced in building sequence libraries based on pre-defined rules, statistical learnings and AI/ML prediction filtering.
• Experience mining data from open-source sequence databases like IMGT, NCBI, GenBank, OAS, PDB, SABDAB, etc.
• Experienced extracting useful information from small to large datasets for the application of AI/ML in biologics discovery, collaborating with AI/ML teams to apply the learning to research projects.
• Familiar with the sequences and structures of different types of biologic therapeutic molecules. Deep understanding of the relationships between sequence and structure and structure and function.
• Experience supporting biologics projects from Discovery to Lead Optimization.

Additional Information:         Location: San Diego, CA

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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