Internship in Computational Biology or Chemistry for Modality Selection (March 2025, 6 months in Basel)

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The Position

In Roche Pharma Research and Early Development (pRED), we discover and develop molecules as novel therapeutics. One class of molecules, known as covalent inhibitors, are of particular interest since it has the potential to target otherwise undruggable proteins and to achieve outstanding efficacy and safety profiles.

One of our ongoing research activities is to integrate heterogenous biological and chemical data to prioritize protein targets that are suitable for a covalent target approach. For this purpose, we look for a motivated bachelor/master student with a solid educational background and hands-on experience of computational biology or chemistry to support our research.

The internship position is located in the Data & Analytics department in pRED and the work is embedded in an interdisciplinary team.

The Opportunity:

• Curate and integrate heterogeneous biological and chemical data

• Build statistical and machine-learning models to predict the propensity of covalent binding

• Create a prototypical interface for users to assess harmonized data and predictions

Impact and main responsibilities: 
 

As an intern, you will be supported and guided by an interdisciplinary team. You are expected to work diligently and independently, and are encouraged to approach the problem creatively. Your main responsibilities include data curation, data integration, model building, and critical analysis of the results. The output will be used by other research scientists for rationale modality selection.

Who You are:

• You have earned a Bachelor's or Master's degree within the past 12 months compared to the start date, or you are currently enrolled in a Bachelor's or Master's degree program in a relevant field (e.g. computational biology, computational chemistry, etc.)

• Strong knowledge of biochemistry or protein biology, and/or chemistry is mandatory.

• Strong skills of problem-solving with the Python programming language are mandatory.

• Experience working with MongoDB or other document-based databases is preferred.

• Experience with data curation and data integration is preferred.

• Proficiency in both written and spoken English.

Additional Information: Start date: March 2025 or upon availability for a period of 6 months. Please indicate your ideal starting date on your application.

Location: This position is based in Basel, Switzerland.
 

Your application: Please upload your CV, with at least two references, and a cover letter. Both documents are mandatory. Optionally, you can include at least one software repository of your previous work in your CV.

Due to regulations, non-EU/EFTA citizens have to provide a certificate from the university stating that an internship is mandatory and the length of the mandatory internship as part of the application documents.

Do you feel excited? Apply now!

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

Roche is an Equal Opportunity Employer.