Preclinical Bioinformatics Lead

About us

Based in Parma, Italy, Chiesi is an international research-focused pharmaceutical and healthcare group with over 85 years’ experience, operating in 31 countries with more than 7,000 employees (Chiesi Group). To achieve its mission of improving people’s quality of life by acting responsibly towards society and the environment, the Group researches, develops and markets innovative drugs in its main therapeutic areas: Discover more here

We are proud to be the largest global pharmaceutical group to be awarded B Corp Certification, a recognition of high social and environmental standards. We are a reliable company that adopts and promotes a transparent and ethical behavior at all levels.

We believe that the success of Chiesi is built and shaped by our people and our strong set of shared Values and Behaviors. Our people make a critical difference to our success, which is why it is vital that we attract and retain the right talent who will continue to enrich our culture by living and breathing our values and behaviors.

In fact, we are a global family made up of different cultures, different genders, generations, ethnicities, abilities, sexual identities and many other enriching diversities. 

Chiesi Research & Development

Our R&D team represents a fundamental asset for the business. It is divided into integrated functional areas focusing on pipeline projects including discovery and preclinical research, global technical development, drug delivery technology, clinical development, regulatory affairs, pharmacovigilance, intellectual property, quality assurance, R&D project and portfolio management.  Headquartered in the new purpose-built and fully integrated Research and Development Centre in Parma (Italy), the team also has important operations in Paris (France), Chippenham (UK), Cary (US), Stockholm (Sweden), Toronto (Canada) and Shanghai (China).

Who we are looking for

Purpose

As a Bioinformatics Lead you will be a part of the to be part of the PPM & R&D Digital Strategy and Execution Support Unit within R&D Project & Portfolio Management organization at the company. 
 

Main Responsibilities

•    Provide bioinformatic expertise to address a wide variety of biological questions by analyzing and interpreting data, generating reports and building systematic internal data repositories.
•    Conduct omics analyses towards target identification and drug mode of action characterization with emphasis on transcriptomic (scRNA-seq), genomic (WGS, WES), and proteomic (MS, Olink) data, to be connected with patient strata and clinical data.
•    Design, build and monitor analysis pipelines of molecular data and omic data (e.g. Nextflow / Snakemake) using cloud computing solutions (AWS, Azure) and code repositories (e.g. Gitlab).
•    Perform initial quality control checks (pre-processing and cleaning) and downstream analysis on data coming from -omics studies.
•    Perform multi-omic data integration approaches, network analysis, and pathway-level statistical analysis to generate new hypotheses and collaborate with scientists on data mining and guiding experimental design.
•    Collect, QC and homogenize public data sets towards their analysis and integration with internally-generated data, provide input to systematic multi-omic data repository creation and management towards drug repositioning.
•    Coordinate and oversee data analysis with external service providers. 

Experience Required

•    PhD in bioinformatics and/or computational biology, with a strong biological/medical background, and minimum of 5 years’ post-graduate experience. 
•    Proficiency in analyzing NGS and single-cell analysis and subcellular analysis and other ‘omics’ data using statistical programming languages (e.g., R/Bioconductor, Python, etc.). 
•    Demonstrated track record of applying bioinformatic analysis, including machine learning techniques and network biology, to integrate and analyze omic and clinical data, preferably within respiratory drug development. 
•    Broad understanding of drug discovery and development, particularly early and late-stage development.
•    Strong publication record as a leading author.

Languages

English fluent

What we offer

You would join a dynamic, fast-growing, challenging and friendly environment.
In Chiesi we firmly believe that our people are our most valuable asset, that is why we invest in continuous training, learning and development. Therefore, we strive to continuously promote and satisfy development needs, paying particular attention to the quality of our working environment and to collective well-being.
We want our people to come to work happy every day, and we know how important it is to find the right work-life balance in order to be able to give our best. That is why we offer flexible working approach, remote working, support in the relocation process, tax assistance service for foreign colleagues and many other people-care services.